Serrapeptase is used for painful conditions including back pain, osteoarthritis, rheumatoid arthritis, osteoporosis, fibromyalgia, carpel tunnel syndrome, migraine headaches, and tension headaches. It is also used for conditions that involve pain and swelling (inflammation) including sinusitis, laryngitis, sore throat, ear infections, swelling after surgery, swelling of a vein with the formation of a blood clot (thrombophlebitis), and inflammatory bowel disease(IBD) including ulcerative colitis and Crohn's disease. Some people use serrapeptase for heart disease and “hardening of the arteries” (atherosclerosis). Women use it for non-cancerous lumpy breasts (fibrocystic breast disease), and nursing mothers use it for breast pain caused by too much milk (breast engorgement). Other uses include treatment of diabetes, leg ulcers, asthma, and pus accumulation (empyema).